Protein Kinase C (530-558) ( ——— )

产品货号. M40351 CAS No. 122613-29-0

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产品名称

Protein Kinase C (530-558)
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Protein Kinase C (530-558) 是蛋白激酶C (PKC) 的肽片段，是一种有效的 PKC 激活剂。Protein Kinase C (530-558) 可显著抑制破骨细胞骨吸收。
产品描述

Protein Kinase C (530-558), a peptide fragment of protein kinase C (PKC), is a potent PKC activator. Protein Kinase C (530-558) significantly inhibits osteoclastic bone resorption.
体外实验

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体内实验

Protein Kinase C (530-558) (1 nM-1 μM, 24 h) causes a dose-responsive inhibition of bone resorption, which is accompanied by a rapid and distinctive change in osteoclast morphology.Cell Viability Assay Cell Line:Osteoclast cell Concentration:1 nM, 10 nM, 100 nM, 1 μM Incubation Time:24 h Result:Showed a dose-responsive, marked inhibition of bone resorption was observed between 10 nM and 1 μM. At 1 μM, resorption was inhibited by more thaln 87 %.
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适应症

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1. Moonga BS, et al. Effects of peptide fragments of protein kinase C on isolated rat osteoclasts. Exp Physiol. 1998 Nov;83(6):717-25.?

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